A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
نویسندگان
چکیده
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 124 39 شماره
صفحات -
تاریخ انتشار 2002